| Charakter | Aktor |
|---|---|
| Jake Sully | Sama Worthingtona |
| Neytiri | Zoe Saldana |
| Pułkownik Miles Quaritch | Stephena Langa |
| Doktor Grace Augustine | Sigourney Weaver |
| Trudy Chacon | Michelle Rodriguez |
| Tsu'tey | Laz Alonso |
| Parker Selfridge | Giovanni Ribisi |
| Norma Spellmana | Joel David Moore |
| Doktor Max Patel | Dileep Rao |
| Eytukan | Wes Studi |
| Mo'at | CCH Pounder |